Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II

Carbonic anhydrases (CAs) catalyze the reversible hydration of CO₂ to HCO₃⁻ and H⁺. The rate-limiting step in this reaction is the shuttle of protons between the catalytic center of the enzyme and the bulk solution. In carbonic anhydrase II (CAII), the fastest and most wide-spread isoform, this H⁺ s...

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