DNA Copy Number Aberrations and Disruption of the p16lnk4a/Rb Pathway in Radiation-Induced and Spontaneous Rat Mammary Carcinomas

Chromosomal amplifications and deletions are thought to be important events in spontaneous and radiation-induced carcinogenesis. To clarify how ionizing radiation induces mammary carcinogenesis, we characterized genomic copy number aberrations for γ-ray-induced rat mammary carcinomas using microarra...

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Veröffentlicht in:	Radiation research 2010-08, Vol.174 (2), p.206-215
Hauptverfasser:	Iizuka, Daisuke, Imaoka, Tatsuhiko, Takabatake, Takashi, Nishimura, Mayumi, Kakinuma, Shizuko, Nishimura, Yukiko, Shimada, Yoshiya
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Carcinogenesis Carcinoma Chromosomes Comparative genomic hybridization DNA Genes Genomics Promoter regions Tumors
Online-Zugang:	Volltext
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