Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like receptor (TLR) (TLR3, -7, -9) signaling, we show these endosomal TLRs are required for optimal production of IgG autoAbs, IgM rheumatoid factor, and other clinical parameters of disease in 2 lupus strains, B6-Fas...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-07, Vol.106 (29), p.12061-12066
Hauptverfasser:	Kono, Dwight H, Haraldsson, M. Katarina, Lawson, Brian R, Pollard, K. Michael, Koh, Yi Ting, Du, Xin, Arnold, Carrie N, Baccala, Roberto, Silverman, Gregg J, Beutler, Bruce A, Theofilopoulos, Argyrios N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Antinuclear - immunology B lymphocytes B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - immunology Biochemistry Biological Sciences Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Endosomes - drug effects Endosomes - immunology Genetic mutation Immune system Immunoglobulin G - immunology Immunoglobulin M - immunology Lipids Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lymphocyte Activation - drug effects Male Mice Mice, Inbred MRL lpr Mutation Mutation - genetics Nucleic acids Nucleic Acids - pharmacology Picrates - pharmacology Rheumatism Rheumatoid Factor - immunology RNA Signal Transduction - drug effects Signal Transduction - immunology Survival Analysis Systemic lupus erythematosus T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology Toll like receptors Toll-Like Receptor 4 - immunology Toll-Like Receptors - immunology
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