Ablation of triadin causes loss of cardiac Ca²⁺ release units, impaired excitation-contraction coupling, and cardiac arrhythmias

Heart muscle excitation-contraction (E-C) coupling is governed by Ca²⁺ release units (CRUs) whereby Ca²⁺ influx via L-type Ca²⁺ channels (Cav1.2) triggers Ca²⁺ release from juxtaposed Ca²⁺ release channels (RyR2) located in junctional sarcoplasmic reticulum (jSR). Although studies suggest that the j...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-05, Vol.106 (18), p.7636-7641
Hauptverfasser:	Chopra, Nagesh, Yang, Tao, Asghari, Parisa, Moore, Edwin D, Huke, Sabine, Akin, Brandy, Cattolica, Robert A, Perez, Claudio F, Hlaing, Thinn, Knollmann-Ritschel, Barbara E.C, Jones, Larry R, Pessah, Isaac N, Allen, Paul D, Franzini-Armstrong, Clara, Knollmann, Björn C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - pathology Arrhythmias, Cardiac - physiopathology Biological Sciences Calcium Calcium - metabolism Calcium Channels, L-Type - metabolism Carrier Proteins - genetics Carrier Proteins - physiology Dyadic relations Dysrhythmias Heart Heart - physiology Heart - physiopathology Mice Mice, Mutant Strains Muscle Proteins - genetics Muscle Proteins - physiology Myocardial Contraction - genetics Myocardium Myocardium - metabolism Myocardium - ultrastructure Proteins Receptors Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Sequence Deletion Ventricular tachycardia
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