engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies

Biomolecular reagents that enable the specific molecular recognition of proteins play a crucial role in basic research as well as medicine. Up to now, antibodies (immunoglobulins) have been widely used for this purpose. Their predominant feature is the vast repertoire of antigen-binding sites that a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-05, Vol.106 (20), p.8198-8203
Hauptverfasser:	Schönfeld, D, Matschiner, G, Chatwell, L, Trentmann, S, Gille, H, Hülsmeyer, M, Brown, N, Kaye, P.M, Schlehuber, S, Hohlbaum, A.M, Skerra, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins - genetics Antibodies Antibodies - chemistry Antigens Antigens, CD - chemistry Antigens, CD - metabolism Binding Sites Biological Sciences Crystal structure Crystallography, X-Ray CTLA-4 Antigen Epitopes Humans Immunoglobulins Indicators and Reagents - chemical synthesis Indicators and Reagents - chemistry Ligands Lipocalin-2 Lipocalins - chemistry Lipocalins - genetics Lipocalins - metabolism Molecular structure Molecules Monoclonal antibodies Protein Binding Protein Conformation Protein Engineering Proteins Proto-Oncogene Proteins - genetics Receptors Structural engineering T cell receptors T lymphocytes
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