Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein

Mammalian cells employ numerous innate cellular mechanisms to inhibit viral replication and spread. Tetherin, also known as Bst-2 or CD317, is a recently identified, IFN-induced, cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. The means by which teth...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-02, Vol.106 (8), p.2886-2891
Hauptverfasser:	Kaletsky, Rachel L, Francica, Joseph R, Agrawal-Gamse, Caroline, Bates, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Antigens, CD - physiology Antivirals Biological Sciences Budding Cell Line Cell lines Cells Ebola virus Ebolavirus - physiology Enzyme-Linked Immunosorbent Assay Filoviridae - growth & development Filoviridae - physiology Filovirus Gene expression Glycoproteins Glycoproteins - metabolism Glycoproteins - physiology GPI-Linked Proteins HeLa cells HIV HIV 1 Human immunodeficiency virus 1 Humans Membrane Glycoproteins - metabolism Membrane Glycoproteins - physiology Mice Microscopy, Electron, Scanning Protein Binding Retrovirus Viral Proteins - metabolism Viral Proteins - physiology Virions Viruses
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