General and Specific Brain Regions Involved in Encoding and Retrieval of Events: What, Where, and When
Remembering an event involves not only what happened, but also where and when it occurred. We measured regional cerebral blood flow by positron emission tomography during initial encoding and subsequent retrieval of item, location, and time information. Multivariate image analysis showed that left f...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1996-10, Vol.93 (20), p.11280-11285 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 93 |
| creator | Nyberg, Lars McIntosh, Anthony R. Cabeza, Roberto Habib, Reza Houle, Sylvain Tulving, Endel |
| description | Remembering an event involves not only what happened, but also where and when it occurred. We measured regional cerebral blood flow by positron emission tomography during initial encoding and subsequent retrieval of item, location, and time information. Multivariate image analysis showed that left frontal brain regions were always activated during encoding, and right superior frontal regions were always activated at retrieval. Pairwise image subtraction analyses revealed information-specific activations at (i) encoding, item information in left hippocampal, location information in right parietal, and time information in left fusiform regions; and (ii) retrieval, item in right inferior frontal and temporal, location in left frontal, and time in anterior cingulate cortices. These results point to the existence of general encoding and retrieval networks of episodic memory whose operations are augmented by unique brain areas recruited for processing specific aspects of remembered events. |
| doi_str_mv | 10.1073/pnas.93.20.11280 |
| format | Article |
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We measured regional cerebral blood flow by positron emission tomography during initial encoding and subsequent retrieval of item, location, and time information. Multivariate image analysis showed that left frontal brain regions were always activated during encoding, and right superior frontal regions were always activated at retrieval. Pairwise image subtraction analyses revealed information-specific activations at (i) encoding, item information in left hippocampal, location information in right parietal, and time information in left fusiform regions; and (ii) retrieval, item in right inferior frontal and temporal, location in left frontal, and time in anterior cingulate cortices. 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We measured regional cerebral blood flow by positron emission tomography during initial encoding and subsequent retrieval of item, location, and time information. Multivariate image analysis showed that left frontal brain regions were always activated during encoding, and right superior frontal regions were always activated at retrieval. Pairwise image subtraction analyses revealed information-specific activations at (i) encoding, item information in left hippocampal, location information in right parietal, and time information in left fusiform regions; and (ii) retrieval, item in right inferior frontal and temporal, location in left frontal, and time in anterior cingulate cortices. These results point to the existence of general encoding and retrieval networks of episodic memory whose operations are augmented by unique brain areas recruited for processing specific aspects of remembered events.</description><subject>Adult</subject><subject>Animals</subject><subject>Behavioral neuroscience</subject><subject>Blood flow</subject><subject>Boluses</subject><subject>Brain Mapping</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Functional Laterality</subject><subject>Hippocampus - physiology</subject><subject>Humans</subject><subject>Image analysis</subject><subject>Image contrast</subject><subject>Image Processing, Computer-Assisted</subject><subject>Image retrieval</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - physiology</subject><subject>Memory encoding</subject><subject>Memory recall</subject><subject>Multivariate Analysis</subject><subject>Positron emission tomography</subject><subject>Time</subject><subject>Tomography, Emission-Computed</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtrFDEUxoModVt9F0GcJ-lDZ5vLXBLxRctaC4VCVXwMuZzZpswm22R2qP99M911sS_6kuTk-32Hc_gQekPwnOCWna69SnPB5jTXhHL8DM0IFqRsKoGfoxnGtC15RauX6DClW4yxqDk-QAec1zWr2hnqzsFDVH2hvC2-r8G4zpniS1TOF9ewdMGn4sKPoR_BFvlv4U2wzi8f-WsYooMxu0NXLEbwQ_pY_LpRw0k-IcLJI5Wf_hV60ak-wevdfYR-fl38OPtWXl6dX5x9vixN3dChtMyqhmpdtbU21FpBCRW8Io3QFFSHGw2a6qoirW7axnDFtVXEKNISpixt2RH6tO273ugVWJNHysvJdXQrFX_LoJx8qnh3I5dhlIwzSrL9w84ew90G0iBXLhnoe-UhbJJs8ywc181_QVJzQRo2gXgLmhhSitDtZyFYThHKKUIpmKS5niLMlnd_77A37DLL-vudPjn_qE87HP-bkN2m7we4HzL6dovepiHEPVthRjF7ALMJucw</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Nyberg, Lars</creator><creator>McIntosh, Anthony R.</creator><creator>Cabeza, Roberto</creator><creator>Habib, Reza</creator><creator>Houle, Sylvain</creator><creator>Tulving, Endel</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19961001</creationdate><title>General and Specific Brain Regions Involved in Encoding and Retrieval of Events: What, Where, and When</title><author>Nyberg, Lars ; McIntosh, Anthony R. ; Cabeza, Roberto ; Habib, Reza ; Houle, Sylvain ; Tulving, Endel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-d3da62bb475bc2dd9212984169b2eaf06beb2b4417b676c8a8bda1ca1713ad273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Behavioral neuroscience</topic><topic>Blood flow</topic><topic>Boluses</topic><topic>Brain Mapping</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Functional Laterality</topic><topic>Hippocampus - physiology</topic><topic>Humans</topic><topic>Image analysis</topic><topic>Image contrast</topic><topic>Image Processing, Computer-Assisted</topic><topic>Image retrieval</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - physiology</topic><topic>Memory encoding</topic><topic>Memory recall</topic><topic>Multivariate Analysis</topic><topic>Positron emission tomography</topic><topic>Time</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nyberg, Lars</creatorcontrib><creatorcontrib>McIntosh, Anthony R.</creatorcontrib><creatorcontrib>Cabeza, Roberto</creatorcontrib><creatorcontrib>Habib, Reza</creatorcontrib><creatorcontrib>Houle, Sylvain</creatorcontrib><creatorcontrib>Tulving, Endel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nyberg, Lars</au><au>McIntosh, Anthony R.</au><au>Cabeza, Roberto</au><au>Habib, Reza</au><au>Houle, Sylvain</au><au>Tulving, Endel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>General and Specific Brain Regions Involved in Encoding and Retrieval of Events: What, Where, and When</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>93</volume><issue>20</issue><spage>11280</spage><epage>11285</epage><pages>11280-11285</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Remembering an event involves not only what happened, but also where and when it occurred. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1996-10, Vol.93 (20), p.11280-11285 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Adult Animals Behavioral neuroscience Blood flow Boluses Brain Mapping Cognition - physiology Female Functional Laterality Hippocampus - physiology Humans Image analysis Image contrast Image Processing, Computer-Assisted Image retrieval Male Memory Memory - physiology Memory encoding Memory recall Multivariate Analysis Positron emission tomography Time Tomography, Emission-Computed |
| title | General and Specific Brain Regions Involved in Encoding and Retrieval of Events: What, Where, and When |
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