Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

Osteoarthritis (OA) is the most common joint disease and typically begins with an aging-related disruption of the articular cartilage surface. Mechanisms leading to the aging-related cartilage surface degeneration remain to be determined. Here, we demonstrate that nonhistone chromatin protein high-m...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-01, Vol.106 (4), p.1181-1186
Hauptverfasser:	Taniguchi, Noboru, Caramés, Beatriz, Ronfani, Lorenza, Ulmer, Ulrich, Komiya, Setsuro, Bianchi, Marco E, Lotz, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging - metabolism Aging - pathology Animals Antibodies Apoptosis Arthritis Articular cartilage Biological Sciences Cartilage Cartilage, Articular - enzymology Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Survival Chondrocytes Chromatin - metabolism Gene expression Gene Expression Regulation HMGB2 Protein - deficiency HMGB2 Protein - genetics HMGB2 Protein - metabolism Humans Joints Joints - enzymology Joints - pathology Knee joint Matrix Metalloproteinases - metabolism Mice Osteoarthritis Osteoarthritis - enzymology Osteoarthritis - metabolism Osteoarthritis - pathology Protein Transport Proteoglycans - metabolism Rodents
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