Apoptosis and APC in Colorectal Tumorigenesis

Tumors result from disruptions in the homeostatic mechanisms that regulate cell birth and cell death. In colon cancer, one of the earliest manifestation of this imbalance is the formation of polyps, caused by somatic and inherited mutations of the adenomatous polyposis coli (APC) tumor suppressor ge...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-07, Vol.93 (15), p.7950-7954
Hauptverfasser:	Morin, Patrice J., Vogelstein, Bert, Kinzler, Kenneth W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli Protein Animals Apoptosis Base Sequence Cell Division Cell growth Cell Line Cell lines Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Cytoskeletal Proteins - biosynthesis Epithelial cells Gene Expression Genes, APC HT29 cells Humans Inductive reasoning Introns Kinetics Mice Molecular Sequence Data Oligodeoxyribonucleotides Plasmids Proteins Recombinant Proteins - biosynthesis Restriction Mapping Transfection Tumor Cells, Cultured Tumors Zinc
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