Reduced Reproductive Performance in Androgen-Resistant Tfm/Tfm Female Mice
Androgen-resistant female mice (Tfm/Tfm) homozygous for the mutant gene Tfm were bred by making use of males chimaeric for the Tfm gene. All seven Tfm/Tfm females found were fertile, confirming that a normal level of androgen receptor protein is not essential for reproduction in female mice. However...
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| Veröffentlicht in: | Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1980-06, Vol.208 (1170), p.1-12 |
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| container_title | Proceedings of the Royal Society of London. Series B, Biological sciences |
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| creator | Lyon, Mary Frances Glenister, P. H. |
| description | Androgen-resistant female mice (Tfm/Tfm) homozygous for the mutant gene Tfm were bred by making use of males chimaeric for the Tfm gene. All seven Tfm/Tfm females found were fertile, confirming that a normal level of androgen receptor protein is not essential for reproduction in female mice. However, when five of the seven were studied throughout their reproductive life they proved to have impaired reproductive performance and premature cessation of reproduction. No impairment of reproduction was seen in heterozygous Tfm/ + females. The ovarian histology suggested that in Tfm/Tfm the normal ageing processes were accelerated. This work is consistent with the work of others in that androgen is involved in the control of follicular maturation and atresia, and that the effect is mediated by the androgen receptor coded by the Tfm locus. |
| doi_str_mv | 10.1098/rspb.1980.0040 |
| format | Article |
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This work is consistent with the work of others in that androgen is involved in the control of follicular maturation and atresia, and that the effect is mediated by the androgen receptor coded by the Tfm locus.</description><identifier>ISSN: 0962-8452</identifier><identifier>ISSN: 0080-4649</identifier><identifier>ISSN: 0950-1193</identifier><identifier>EISSN: 1471-2954</identifier><identifier>EISSN: 2053-9193</identifier><identifier>DOI: 10.1098/rspb.1980.0040</identifier><identifier>PMID: 6105650</identifier><language>eng</language><publisher>London: The Royal Society</publisher><subject>Androgen receptors ; Androgens ; Androgens - pharmacology ; Animals ; Crosses, Genetic ; Drug Resistance ; Female ; Female animals ; Fertility ; Follicles ; Genes ; Infertility, Female - physiopathology ; Litter Size ; Male ; Male animals ; Mice ; Mice, Inbred Strains ; Oocytes ; Ovaries ; Ovary - physiopathology ; Pregnancy ; Receptors ; Receptors, Androgen - physiology ; Reproduction - drug effects</subject><ispartof>Proceedings of the Royal Society of London. 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H.</creatorcontrib><title>Reduced Reproductive Performance in Androgen-Resistant Tfm/Tfm Female Mice</title><title>Proceedings of the Royal Society of London. Series B, Biological sciences</title><addtitle>Proc. R. Soc. Lond. B</addtitle><addtitle>Proc. R. Soc. Lond. B</addtitle><description>Androgen-resistant female mice (Tfm/Tfm) homozygous for the mutant gene Tfm were bred by making use of males chimaeric for the Tfm gene. All seven Tfm/Tfm females found were fertile, confirming that a normal level of androgen receptor protein is not essential for reproduction in female mice. However, when five of the seven were studied throughout their reproductive life they proved to have impaired reproductive performance and premature cessation of reproduction. No impairment of reproduction was seen in heterozygous Tfm/ + females. The ovarian histology suggested that in Tfm/Tfm the normal ageing processes were accelerated. This work is consistent with the work of others in that androgen is involved in the control of follicular maturation and atresia, and that the effect is mediated by the androgen receptor coded by the Tfm locus.</description><subject>Androgen receptors</subject><subject>Androgens</subject><subject>Androgens - pharmacology</subject><subject>Animals</subject><subject>Crosses, Genetic</subject><subject>Drug Resistance</subject><subject>Female</subject><subject>Female animals</subject><subject>Fertility</subject><subject>Follicles</subject><subject>Genes</subject><subject>Infertility, Female - physiopathology</subject><subject>Litter Size</subject><subject>Male</subject><subject>Male animals</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Oocytes</subject><subject>Ovaries</subject><subject>Ovary - physiopathology</subject><subject>Pregnancy</subject><subject>Receptors</subject><subject>Receptors, Androgen - physiology</subject><subject>Reproduction - drug effects</subject><issn>0962-8452</issn><issn>0080-4649</issn><issn>0950-1193</issn><issn>1471-2954</issn><issn>2053-9193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1980</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UUtv1DAYjBCobAtXDkhIOfWW3c-xndgHDm1peaiI1bJw4GLl8bn1khd2Ulh-Pc5mtaJC9GDZ1sx8nhkHwQsCcwJSLKzr8jmRAuYADB4FM8JSEsWSs8fBDGQSR4Lx-Glw7NwGACQX_Cg4SgjwhMMs-LDCciiwDFfY2dYfe3OH4RKtbm2dNQWGpgnPmtK2N9hEK3TG9VnTh2tdL_wKr7DOKgw_mgKfBU90Vjl8vt9Pgi9Xl-uLd9H1p7fvL86uoyIRoo-YBs1pInWa6FxSSHVcALKMZxDHMcGcouRUSFrkQpZUMJqUsT8BL3WmgdKT4HSa6w3_GND1qjauwKrKGmwHp1IeE8oY88T5RCxs65xFrTpr6sxuFQE1lqfG8tRYnhrL84JX-8lDXmN5oO_b8ribcNtufcK2MNhv1aYdbOOvavV5eU4kl3cxCENI6qcKSiAlLCbqt-l2z40E5QnKODeg2tHu2_jXFX3o1f9meTmpNq5v7SEK5b5xD0YT6H8Tfx3AzH5XSUpTrr4Kpt6s5fIbnDOVeP5i4t-am9ufxqK658VfOuvyXaxdIOIVrx9UjGaLtumx6f-SKT1UlepKTf8ANDTfeg</recordid><startdate>19800623</startdate><enddate>19800623</enddate><creator>Lyon, Mary Frances</creator><creator>Glenister, P. H.</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19800623</creationdate><title>Reduced Reproductive Performance in Androgen-Resistant Tfm/Tfm Female Mice</title><author>Lyon, Mary Frances ; Glenister, P. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c688t-4f0f5369f76fb9307f2c0e4a5a02221eb3e953893cb89d38436d289d05dfaf033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1980</creationdate><topic>Androgen receptors</topic><topic>Androgens</topic><topic>Androgens - pharmacology</topic><topic>Animals</topic><topic>Crosses, Genetic</topic><topic>Drug Resistance</topic><topic>Female</topic><topic>Female animals</topic><topic>Fertility</topic><topic>Follicles</topic><topic>Genes</topic><topic>Infertility, Female - physiopathology</topic><topic>Litter Size</topic><topic>Male</topic><topic>Male animals</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Oocytes</topic><topic>Ovaries</topic><topic>Ovary - physiopathology</topic><topic>Pregnancy</topic><topic>Receptors</topic><topic>Receptors, Androgen - physiology</topic><topic>Reproduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lyon, Mary Frances</creatorcontrib><creatorcontrib>Glenister, P. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyon, Mary Frances</au><au>Glenister, P. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Reproductive Performance in Androgen-Resistant Tfm/Tfm Female Mice</atitle><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle><stitle>Proc. R. Soc. Lond. B</stitle><addtitle>Proc. R. Soc. Lond. B</addtitle><date>1980-06-23</date><risdate>1980</risdate><volume>208</volume><issue>1170</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>0962-8452</issn><issn>0080-4649</issn><issn>0950-1193</issn><eissn>1471-2954</eissn><eissn>2053-9193</eissn><abstract>Androgen-resistant female mice (Tfm/Tfm) homozygous for the mutant gene Tfm were bred by making use of males chimaeric for the Tfm gene. All seven Tfm/Tfm females found were fertile, confirming that a normal level of androgen receptor protein is not essential for reproduction in female mice. However, when five of the seven were studied throughout their reproductive life they proved to have impaired reproductive performance and premature cessation of reproduction. No impairment of reproduction was seen in heterozygous Tfm/ + females. The ovarian histology suggested that in Tfm/Tfm the normal ageing processes were accelerated. This work is consistent with the work of others in that androgen is involved in the control of follicular maturation and atresia, and that the effect is mediated by the androgen receptor coded by the Tfm locus.</abstract><cop>London</cop><pub>The Royal Society</pub><pmid>6105650</pmid><doi>10.1098/rspb.1980.0040</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0962-8452 |
| ispartof | Proceedings of the Royal Society of London. Series B, Biological sciences, 1980-06, Vol.208 (1170), p.1-12 |
| issn | 0962-8452 0080-4649 0950-1193 1471-2954 2053-9193 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Androgen receptors Androgens Androgens - pharmacology Animals Crosses, Genetic Drug Resistance Female Female animals Fertility Follicles Genes Infertility, Female - physiopathology Litter Size Male Male animals Mice Mice, Inbred Strains Oocytes Ovaries Ovary - physiopathology Pregnancy Receptors Receptors, Androgen - physiology Reproduction - drug effects |
| title | Reduced Reproductive Performance in Androgen-Resistant Tfm/Tfm Female Mice |
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