Retinoid Receptor Antisense DNAs Inhibit Alkaline Phosphatase Induction and Clonogenicity in Malignant Keratinocytes

Antisense oligodeoxynucleotides [oligo(dN)s] corresponding to human cellular retinol-binding protein I (cRBP) and human nuclear retinoic acid receptor α (hnRAR) were synthesized. Exposure of human malignant keratinocytes to these oligo(dN)s significantly attenuated the level of cytoplasmic cRBP and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1989-07, Vol.86 (14), p.5590-5594
Hauptverfasser:	Cope, Frederick O., Wille, John J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - biosynthesis Base Sequence Biological and medical sciences Carcinoma, Squamous Cell Carrier Proteins - genetics Carrier Proteins - physiology Cell culture techniques Cell differentiation, maturation, development, hematopoiesis Cell growth Cell nucleus Cell physiology Cells Cytoplasm Enzyme Induction Epidermis Fundamental and applied biological sciences. Psychology Humans Keratinocytes Legends Molecular and cellular biology Neoplasm Proteins - genetics Oligonucleotides - pharmacology Oligonucleotides, Antisense Phosphatases Receptors Receptors, Retinoic Acid Retinoids Retinol-Binding Proteins - genetics Retinol-Binding Proteins, Cellular Tongue Neoplasms Tumor Stem Cell Assay
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