Pharmacologic Ascorbic Acid Concentrations Selectively Kill Cancer Cells: Action as a Pro-Drug to Deliver Hydrogen Peroxide to Tissues

Human pharmacokinetics data indicate that i.v. ascorbic acid (ascorbate) in pharmacologic concentrations could have an unanticipated role in cancer treatment. Our goals here were to test whether ascorbate killed cancer cells selectively, and if so, to determine mechanisms, using clinically relevant...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-09, Vol.102 (38), p.13604-13609
Hauptverfasser:	Chen, Qi, Espey, Michael Graham, Krishna, Murali C., Mitchell, James B., Corpe, Christopher P., Buettner, Garry R., Shacter, Emily, Levine, Mark, Rall, J. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antioxidants - pharmacokinetics Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis - drug effects Ascorbic Acid - pharmacokinetics Ascorbic Acid - pharmacology Ascorbic Acid - therapeutic use Biological Sciences Blood Cancer Cell death Cell Line, Tumor Cell lines Cells Delta cells Dose-Response Relationship, Drug Erythrocytes Free Radicals - metabolism Humans Hydrogen Peroxide - metabolism Killing Lymphocytes Lymphoma Lymphoma - drug therapy Lymphoma - metabolism Medical treatment Oxidation-Reduction - drug effects Pharmacology Prodrugs - pharmacokinetics Prodrugs - pharmacology Prodrugs - therapeutic use
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