Neutrophil Microtubules Suppress Polarity and Enhance Directional Migration

How do microtubules, which maintain and direct polarity of many eukaryotic cells, regulate polarity of blood neutrophils? In sharp contrast to most cells, disrupting a neutrophil's microtubule network with nocodazole causes it to polarize and migrate [Niggli, V. (2003) J. Cell Sci. 116, 813-822...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-05, Vol.102 (19), p.6884-6889
Hauptverfasser:	Xu, Jingsong, Wang, Fei, Van Keymeulen, Alexandra, Rentel, Maike, Bourne, Henry R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Antineoplastic Agents - pharmacology Biological Sciences Cell adhesion & migration Cell lines Cell Membrane - metabolism Cell membranes Cell Movement Cell nucleus Cellular biology Chemotactic factors Chemotaxis DNA, Complementary - metabolism Fluorescence Green Fluorescent Proteins - metabolism HL-60 Cells Humans Inhibitor drugs Microtubule organizing center Microtubules Microtubules - metabolism N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils Neutrophils - metabolism Nocodazole - pharmacology Protein Transport Signal Transduction Time Factors Transfection
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