Late-Onset Motoneuron Disease Caused by a Functionally Modified AMPA Receptor Subunit

Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system in middle and old age that leads to progressive loss of spinal motoneurons. Transgenic mice overexpressing mutated human Cu2+/ Zn2+superoxide dismutase 1 (SOD1) reproduce clinical features of the familial for...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-04, Vol.102 (16), p.5826-5831
Hauptverfasser:	Kuner, Rohini, Groom, Anthony J., Bresink, Iris, Kornau, Hans-Christian, Stefovska, Vanya, Müller, Gerald, Hartmann, Bettina, Tschauner, Karsten, Waibel, Stefan, Ludolph, Albert C., Ikonomidou, Chrysanthy, Seeburg, Peter H., Turski, Lechoslaw, Lindauer, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	AMPA receptors Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - etiology Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Animals Biological Sciences Brain Brain - cytology Brain - pathology Calcium - metabolism Cobalt - metabolism Electromyography Gene expression Humans In Situ Hybridization Messenger RNA Mice Mice, Inbred BALB C Mice, Transgenic Motor ability Motor Activity - physiology Mutation Nervous system Nervous system diseases Neurons Neurons - metabolism Neurons - pathology Neurons - ultrastructure Protein Subunits - genetics Protein Subunits - metabolism Receptors, AMPA - genetics Receptors, AMPA - metabolism Reflex - physiology Reflexes Rodents Spinal cord Spinal Cord - cytology Spinal Cord - pathology Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Transgenic animals
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