AML1-ETO Fusion Protein up-Regulates TRKA mRNA Expression in Human CD34+Cells, Allowing Nerve Growth Factor-Induced Expansion

The AML1-ETO fusion protein, generated by the t(8;21) in acute myeloid leukemia (AML), exerts dominant-negative functions and a variety of gains of function, including a positive effect on the growth of primary human CD34+hematopoietic stem/progenitor cells. We now show that AML1-ETO expression up-r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-03, Vol.102 (11), p.4016-4021
Hauptverfasser:	Mulloy, James C., Jankovic, Vladimir, Wunderlich, Mark, Delwel, Ruud, Cammenga, Jorg, Krejci, Ondrej, Zhao, Hui, Peter J. M. Valk, Lowenberg, Bob, Nimer, Stephen D., Rowley, Janet D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD34 - immunology Biological Sciences Cell Division - physiology Cell growth Cell lines Cellular biology Core Binding Factor Alpha 2 Subunit Cultured cells Cytokines Gene expression Gene Expression Regulation - physiology Genes Hematopoietic stem cells Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Humans Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - metabolism Messenger RNA Myeloid leukemia Nerve Growth Factor - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Proteins Quantitative genetics Receptor, trkA - biosynthesis Receptor, trkA - genetics RUNX1 Translocation Partner 1 Protein Stem cells Stromal cells Transcription Factors - genetics Transcription Factors - metabolism Translocation, Genetic Up-Regulation
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