Cotranslational Integration and Initial Sorting at the Endoplasmic Reticulum Translocon of Proteins Destined for the Inner Nuclear Membrane

The current diffusion-retention model for protein trafficking to the inner nuclear membrane (INM) proposes that INM proteins diffuse laterally from the membrane of the endoplasmic reticulum into the INM and are then retained in the INM by binding to nuclear proteins or DNA. Because some data indicat...

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