Modified Amino Acid Copolymers Suppress Myelin Basic Protein 85-99-Induced Encephalomyelitis in Humanized Mice through Different Effects on T Cells

A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) protein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85-99-specific HLA-DR2-restricted T cell receptor from an MS patient has been used to examine the effectiveness of modified amino acid copolymers poly(F,Y,A,K)n an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-08, Vol.101 (32), p.11749-11754
Hauptverfasser:	Illés, Zsolt, Joel N. H. Stern, Reddy, Jayagopala, Waldner, Hanspeter, Mycko, Marcin P., Brosnan, Celia F., Ellmerich, Stephan, Altmann, Daniel M., Santambrogio, Laura, Strominger, Jack L., Kuchroo, Vijay K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Biological Sciences Central nervous system Copolymers Cytokines Cytokines - drug effects Cytokines - secretion Demyelinating diseases Drug Therapy, Combination Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - prevention & control Glatiramer Acetate HLA-DR2 Antigen Humans Immunization Immunology Mice Mice, Transgenic Myelin Basic Protein - pharmacology Nervous system diseases Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptide Fragments - therapeutic use Peptides - administration & dosage Peptides - therapeutic use Proteins Receptors, Antigen, T-Cell - immunology Splenocytes T cell antigen receptors T lymphocytes T-Lymphocytes - drug effects T-Lymphocytes - immunology Treatment Outcome Vaccination
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