Illegitimate WNT Signaling Promotes Proliferation of Multiple Myeloma Cells

The unrestrained growth of tumor cells is generally attributed to mutations in essential growth control genes, but tumor cells are also influenced by signals from the environment. In multiple myeloma (MM), the factors and signals coming from the bone marrow microenvironment are possibly even essenti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (16), p.6122-6127
Hauptverfasser:	Patrick W. B. Derksen, Tjin, Esther, Meijer, Helen P., Klok, Melanie D., Harold D. Mac Gillavry, Marinus H. J. van Oers, Lokhorst, Henk M., Bloem, Andries C., Clevers, Hans, Nusse, Roel, van der Neut, Ronald, Spaargaren, Marcel, Pals, Steven T., Weissman, Irving L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies B lymphocytes beta Catenin Biological Sciences Cancer Cell Division - physiology Cell growth Cell lines Cells, Cultured Cultured cells Cytoskeletal Proteins - metabolism Humans Immunohistochemistry Immunology L cells Microscopy, Fluorescence Multiple Myeloma - metabolism Multiple Myeloma - pathology Plasma Plasma cells Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins - physiology Signal Transduction - physiology Stem cells T lymphocytes Trans-Activators - metabolism Tumor Cells, Cultured Tumors Wnt Proteins Zebrafish Proteins
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