Catalytic Asymmetric Addition of Diorganozinc Reagents to N-Phosphinoylalkylimines

The synthesis of α-chiral amines bearing two alkyl groups has been hampered by the accessibility and stability of the alkylimine precursor. Herein, we report an efficient strategy to generate the alkyl-substituted imine in situ that is compatible with the MeDuPHOS monoxide·Cu(I) catalyzed addition o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-04, Vol.101 (15), p.5405-5410
Hauptverfasser:	Côté, Alexandre, Boezio, Alessandro A., Charette, André B., Halpern, Jack
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Aldehydes Amides Amines Asymmetric Catalysis Special Feature Part I Chemical compounds Copper Imines Ligands Organic chemistry Physical Sciences Reagents Solvents Sulfinic acids
Online-Zugang:	Volltext
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