Extrapancreatic Insulin-Producing Cells in Multiple Organs in Diabetes

Insulin-producing cells normally occur only in the pancreas and thymus. Surprisingly, we found widespread insulin mRNA and protein expression in different diabetic mouse and rat models, including streptozotocin-treated mice and rats, ob/ob mice, and mice fed high-fat diets. We detected in diabetic m...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (8), p.2458-2463
Hauptverfasser:	Kojima, Hideto, Fujimiya, Mineko, Matsumura, Kazuhiro, Nakahara, Tamio, Hara, Manami, Chan, Lawrence, O'Malley, Bert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - metabolism Adipose tissues Animals B lymphocytes Biological Sciences Bone marrow Bone Marrow Cells - metabolism Diabetes Diabetes complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - physiopathology Hyperglycemia In Situ Hybridization Insulin Insulin - genetics Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Liver Liver - metabolism Liver cells Mice Obesity Organ Specificity Pancreas Polymerase Chain Reaction Proinsulin - genetics RNA, Messenger - genetics Spleen - metabolism Transplants & implants Type 1 diabetes mellitus
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