Genetic and functional confirmation of the causality of the DGAT1 K232A quantitative trait nucleotide in affecting milk yield and composition

We recently used a positional cloning approach to identify a nonconservative lysine to alanine substitution (K232A) in the bovine DGAT1 gene that was proposed to be the causative quantitative trait nucleotide underlying a quantitative trait locus (QTL) affecting milk fat composition, previously mapp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2004-02, Vol.101 (8), p.2398-2403
Hauptverfasser:	Grisart, B, Farnir, F, Karim, L, Cambisano, N, Kim, J.J, Kvasz, A, Mni, M, Simon, P, Frere, J.M, Coppieters, W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism Alleles Alternative splicing Amino Acid Substitution Animals Bacteria Base Sequence Biological Sciences Bos Cattle - genetics Cell Line Chromosome Mapping DGAT1 gene Diacylglycerol O-Acyltransferase DNA Primers Female Genetic Markers Genetic mutation Genetics Genotypes Haplotypes Lactation Life sciences Linkage Disequilibrium Male Mammary Glands, Animal Messenger RNA Milk Milk - metabolism Milk fat Mutagenesis, Site-Directed Médecine vétérinaire & santé animale Quantitative Trait Loci Quantitative traits Recombinant Proteins - metabolism Reverse Transcriptase Polymerase Chain Reaction Sciences du vivant Spodoptera Triglycerides Veterinary medicine & animal health
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