Mouse Ribonucleotide Reductase R2 Protein: A New Target for Anaphase-Promoting Complex-Cdh1-Mediated Proteolysis

Ribonucleotide reductase consists of two nonidentical proteins, R1 and R2, and catalyzes the rate-limiting step in DNA precursor synthesis: the reduction of ribonucleotides to deoxyribonucleotides. A strictly balanced supply of deoxyribonucleotides is essential for both accurate DNA replication and...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-04, Vol.100 (7), p.3925-3929
Hauptverfasser:	Chabes, Anna Lena, Pfleger, Cathie M., Kirschner, Marc W., Thelander, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Amino Acid Sequence Anaphase - physiology Anaphase-Promoting Complex-Cyclosome Animals Apoptosis - physiology Biological Sciences Cell cycle Cells Conserved Sequence Cricetinae Cytometry DNA damage Guinea Pigs Humans Immunoblotting Interphase Ligases - metabolism Mice Mitosis Molecular Sequence Data Oxidation-Reduction Proteins Recombinant Proteins - chemistry Recombinant Proteins - metabolism Ribonucleic acid Ribonucleotide Reductases - chemistry Ribonucleotide Reductases - genetics Ribonucleotide Reductases - metabolism Ribonucleotides RNA Rodents Sequence Alignment Sequence Homology, Amino Acid Starvation Substrate Specificity Transfection Ubiquitin - metabolism Ubiquitin-Protein Ligase Complexes
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