Degradation of p57Kip2Mediated by SCFSkp2-Dependent Ubiquitylation

The abundance of the cyclin-dependent kinase (CDK) inhibitor p57Kip2, an important regulator of cell cycle progression, is thought to be controlled by the ubiquitin-proteasome pathway. The Skp1/Cul1/F-box (SCF)-type E3 ubiquitin ligase complex SCFSkp2has now been shown to be responsible for regulati...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (18), p.10231-10236
Hauptverfasser:	Kamura, Takumi, Hara, Taichi, Kotoshiba, Shuhei, Yada, Masayoshi, Ishida, Noriko, Imaki, Hiroyuki, Hatakeyama, Shigetsugu, Nakayama, Keiko, Nakayama, Keiichi I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell cycle Cell cycle proteins Complementary DNA Cultured cells Cyclins Epitopes HeLa cells Humans Phosphorylation Ubiquitins
Online-Zugang:	Volltext
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