Rho-Dependent Formation of Epithelial "Leader" Cells during Wound Healing

The motile behavior of epithelial cells located at the edge of a large wound in a monolayer of cultured cells was analyzed. The initial cellular response is alignment of the edge with an accompanying formation of tangential marginal actin bundles within individual cells positioned along the wound ed...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-09, Vol.100 (19), p.10788-10793
Hauptverfasser:	Omelchenko, T., Vasiliev, J. M., Gelfand, I. M., Feder, H. H., Bonder, E. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Amides - pharmacology Animals Biological Sciences Cell adhesion & migration Cell culture Cell lines Cell Movement Cells Cellular biology Cultured cells Cytoplasm Cytoskeleton Enzyme Inhibitors - pharmacology Epithelial cells Microfilaments Microscopy, Fluorescence Microtubules Pseudopodia Pyridines - pharmacology Rats rhoA GTP-Binding Protein - physiology Wound healing Wound Healing - physiology
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