Transcriptional Profiling of the Sonic Hedgehog Response: A Critical Role for N-myc in Proliferation of Neuronal Precursors

Cerebellar granule cells are the most abundant neurons in the brain, and granule cell precursors (GCPs) are a common target of transformation in the pediatric brain tumor medulloblastoma. Proliferation of GCPs is regulated by the secreted signaling molecule Sonic hedgehog (Shh), but the mechanisms b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2003-06, Vol.100 (12), p.7331-7336
Hauptverfasser:	Oliver, Trudy G., Grasfeder, Linda L., Carroll, Audra L., Kaiser, Constanze, Gillingham, Christine L., Lin, Simon M., Wickramasinghe, Rasika, Scott, Matthew P., Wechsler-Reya, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain Cell cycle Cell Cycle - genetics Cell Division - genetics Cell growth Cells Cerebellar Neoplasms - etiology Cerebellar Neoplasms - genetics Cerebellum Cerebellum - cytology Cerebellum - metabolism Cyclins Gene Expression Profiling Genes Genes, bcl-1 Genes, myc Hedgehog Proteins Medulloblastoma Medulloblastoma - etiology Medulloblastoma - genetics Membrane Proteins - genetics Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Mutant Strains Neurology Neurons Neurons - cytology Neurons - metabolism Oligonucleotide Array Sequence Analysis Patched Receptors Receptors, Cell Surface Retroviridae RNA Signal Transduction Stem cells Stem Cells - cytology Stem Cells - metabolism Trans-Activators - genetics Tumors Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!