Genomic imprinting of two antagonistic loci
We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed f...
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| Veröffentlicht in: | Proceedings of the Royal Society. B, Biological sciences Biological sciences, 2001-09, Vol.268 (1479), p.1861-1867 |
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| container_issue | 1479 |
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| container_title | Proceedings of the Royal Society. B, Biological sciences |
| container_volume | 268 |
| creator | Wilkins, Jon F. Haig, David |
| description | We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted growth suppressor locus only from the maternally derived allele. In addition, our coevolutionary model allows us to make predictions regarding the sequence of evolutionary events necessary for generating such a system. We conclude that imprinting at the growth factor locus preceded the evolution of growth suppressor function at the second locus, which in turn preceded imprinting at that locus. We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 -insulin-like growth factor 2 receptor system of mammals. |
| doi_str_mv | 10.1098/rspb.2001.1651 |
| format | Article |
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With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted growth suppressor locus only from the maternally derived allele. In addition, our coevolutionary model allows us to make predictions regarding the sequence of evolutionary events necessary for generating such a system. We conclude that imprinting at the growth factor locus preceded the evolution of growth suppressor function at the second locus, which in turn preceded imprinting at that locus. We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 -insulin-like growth factor 2 receptor system of mammals.</description><identifier>ISSN: 0962-8452</identifier><identifier>EISSN: 1471-2954</identifier><identifier>DOI: 10.1098/rspb.2001.1651</identifier><identifier>PMID: 11564340</identifier><language>eng</language><publisher>England: The Royal Society</publisher><subject>Alleles ; Animals ; Antagonistic Coevolution ; Ecological competition ; Evolution ; Evolutionary Stability ; Genetic loci ; Genetic mutation ; Genomic Imprinting ; Growth Factor ; Growth Suppressor ; Humans ; Igf2 ; Insulin-Like Growth Factor II - genetics ; Mammals ; Models, Genetic ; Receptor, IGF Type 2 - genetics ; Receptors ; Somatomedins ; Taxa</subject><ispartof>Proceedings of the Royal Society. B, Biological sciences, 2001-09, Vol.268 (1479), p.1861-1867</ispartof><rights>Copyright 2001 The Royal Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c794t-c881b99e9f148e35e8186c3c02c10f5411d68a3100dbfc30ad3e2017ce83b5fd3</citedby><cites>FETCH-LOGICAL-c794t-c881b99e9f148e35e8186c3c02c10f5411d68a3100dbfc30ad3e2017ce83b5fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3067792$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3067792$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27904,27905,53771,53773,57997,58230</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11564340$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilkins, Jon F.</creatorcontrib><creatorcontrib>Haig, David</creatorcontrib><title>Genomic imprinting of two antagonistic loci</title><title>Proceedings of the Royal Society. B, Biological sciences</title><addtitle>Proc Biol Sci</addtitle><description>We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted growth suppressor locus only from the maternally derived allele. In addition, our coevolutionary model allows us to make predictions regarding the sequence of evolutionary events necessary for generating such a system. We conclude that imprinting at the growth factor locus preceded the evolution of growth suppressor function at the second locus, which in turn preceded imprinting at that locus. We then discuss the consistency of these predictions with currently available comparative data on the insulin-like growth factor 2 -insulin-like growth factor 2 receptor system of mammals.</description><subject>Alleles</subject><subject>Animals</subject><subject>Antagonistic Coevolution</subject><subject>Ecological competition</subject><subject>Evolution</subject><subject>Evolutionary Stability</subject><subject>Genetic loci</subject><subject>Genetic mutation</subject><subject>Genomic Imprinting</subject><subject>Growth Factor</subject><subject>Growth Suppressor</subject><subject>Humans</subject><subject>Igf2</subject><subject>Insulin-Like Growth Factor II - genetics</subject><subject>Mammals</subject><subject>Models, Genetic</subject><subject>Receptor, IGF Type 2 - genetics</subject><subject>Receptors</subject><subject>Somatomedins</subject><subject>Taxa</subject><issn>0962-8452</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYrsLV04I9cQFpXjsOLEvCNiF5WMlqmXhOkocp3VJ4mInu5Rfj9NUhQqxnCxrnnnn450oegRkBkSK586vixklBGaQcrgTTSDJIKaSJ3ejCZEpjUXC6VF07P2KECK54PejIwCeJiwhk-jZuW5tY9TUNGtn2s60i6mtpt2NneZtly9sa3wXwrVV5kF0r8prrx_u3pPoy9s3V6fv4otP5-9PX13EKpNJFyshoJBSywoSoRnXAkSqmCJUAal4AlCmImdASFlUipG8ZJoSyJQWrOBVyU6iF6Puui8aXSrddi6vMfTX5G6DNjd4GGnNEhf2GoEIISgJAk93As5-77XvsDFe6brOW217jxmA4JSy_4IgKMuoGMDZCCpnvXe62ncDBAcjcDACByNwMCIkPPlzht_4bvMBYCPg7CYsM6xXdxtc2d614ftvWX9b1uXn-WuQklzTVJhwCRKJCIvOgAHFn2a9lRsADAAa73uNW-ywzN9VH49VV76zbj8LI2mWSRrC8RgOp6J_7MO5-4ZpxjKOX0WCHy7nVx_P5kEx8C9HfmkWyxvjNB5Msy2ubNsFd7d9bjsMNwRY9XW4g7IKEvRWCbtZO18cZrNf8Rj73Q</recordid><startdate>20010922</startdate><enddate>20010922</enddate><creator>Wilkins, Jon F.</creator><creator>Haig, David</creator><general>The Royal Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20010922</creationdate><title>Genomic imprinting of two antagonistic loci</title><author>Wilkins, Jon F. ; Haig, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c794t-c881b99e9f148e35e8186c3c02c10f5411d68a3100dbfc30ad3e2017ce83b5fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Animals</topic><topic>Antagonistic Coevolution</topic><topic>Ecological competition</topic><topic>Evolution</topic><topic>Evolutionary Stability</topic><topic>Genetic loci</topic><topic>Genetic mutation</topic><topic>Genomic Imprinting</topic><topic>Growth Factor</topic><topic>Growth Suppressor</topic><topic>Humans</topic><topic>Igf2</topic><topic>Insulin-Like Growth Factor II - genetics</topic><topic>Mammals</topic><topic>Models, Genetic</topic><topic>Receptor, IGF Type 2 - genetics</topic><topic>Receptors</topic><topic>Somatomedins</topic><topic>Taxa</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wilkins, Jon F.</creatorcontrib><creatorcontrib>Haig, David</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkins, Jon F.</au><au>Haig, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic imprinting of two antagonistic loci</atitle><jtitle>Proceedings of the Royal Society. B, Biological sciences</jtitle><addtitle>Proc Biol Sci</addtitle><date>2001-09-22</date><risdate>2001</risdate><volume>268</volume><issue>1479</issue><spage>1861</spage><epage>1867</epage><pages>1861-1867</pages><issn>0962-8452</issn><eissn>1471-2954</eissn><abstract>We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. 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| ispartof | Proceedings of the Royal Society. B, Biological sciences, 2001-09, Vol.268 (1479), p.1861-1867 |
| issn | 0962-8452 1471-2954 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central |
| subjects | Alleles Animals Antagonistic Coevolution Ecological competition Evolution Evolutionary Stability Genetic loci Genetic mutation Genomic Imprinting Growth Factor Growth Suppressor Humans Igf2 Insulin-Like Growth Factor II - genetics Mammals Models, Genetic Receptor, IGF Type 2 - genetics Receptors Somatomedins Taxa |
| title | Genomic imprinting of two antagonistic loci |
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