Sonic Hedgehog Rescues Cranial Neural Crest from Cell Death Induced by Ethanol Exposure

Alcohol is a teratogen that induces a variety of abnormalities including brain and facial defects [Jones, K. & Smith, D. (1973) Lancet 2, 999-1001], with the exact nature of the deficit depending on the time and magnitude of the dose of ethanol to which developing fetuses are exposed. In additio...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2002-08, Vol.99 (16), p.10476-10481
Hauptverfasser:	Ahlgren, Sara C., Thakur, Vijaya, Bronner-Fraser, Marianne
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Animals Antibodies Biological Sciences Birth defects Body Patterning Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics Brain - embryology Cell Death Cell nucleus Cellular biology Chick Embryo DNA-Binding Proteins - genetics Embryos Ethanol Ethanol - pharmacology Fetuses Fibroblast Growth Factor 8 Fibroblast Growth Factors - genetics Gene Expression Hedgehog Proteins Kruppel-Like Transcription Factors Membrane Proteins - genetics Messenger RNA Nerve Tissue Proteins Neural crest Neural Crest - drug effects Neural Crest - embryology Neurons Patched Receptors Proto-Oncogene Proteins - genetics Receptors, Cell Surface - genetics Receptors, G-Protein-Coupled Repressor Proteins RNA Signal Transduction Smoothened Receptor Trans-Activators - genetics Trans-Activators - metabolism Transcription Factors - genetics Transforming Growth Factor beta Wnt Proteins Xenopus Proteins Zebrafish Proteins Zinc Finger Protein Gli2 Zinc Finger Protein Gli3
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