Oral Immunization with Hepatitis B Surface Antigen Expressed in Transgenic Plants

Oral immunogenicity of recombinant hepatitis B surface antigen (HBsAg) derived from yeast (purified product) or in transgenic potatoes (uncooked unprocessed sample) was compared. An oral adjuvant, cholera toxin, was used to increase immune responses. Transgenic plant material containing HBsAg was th...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-09, Vol.98 (20), p.11539-11544
Hauptverfasser:	Kong, Qingxian, Richter, Liz, Yang, Yu Fang, Arntzen, Charles J., Mason, Hugh S., Thanavala, Yasmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Biological Sciences Flowers & plants Genetic Vectors Hepatitis Hepatitis antigens Hepatitis B Hepatitis B - immunology hepatitis B surface antigen Hepatitis B Surface Antigens - immunology Hepatitis B virus Immune response Immunization Immunology Mice Plants, Genetically Modified - immunology Plasmids Potatoes Solanum tuberosum Solanum tuberosum - immunology Transgenic animals Tubers Vaccination Vaccines
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