Three-Dimensional Domain Swapping in p13suc1 Occurs in the Unfolded State and is Controlled by Conserved Proline Residues

p13suc1 has two native states, a monomer and a domain-swapped dimer. We show that their folding pathways are connected by the denatured state, which introduces a kinetic barrier between monomer and dimer under native conditions. The barrier is lowered under conditions that speed up unfolding, thereb...

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