Anti-Apoptotic Signaling by Hepatocyte Growth Factor/Met via the Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Pathways

Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We sought to determine the role of HGF/Met in apoptosis and identify signal transducers involved in this process. In exp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (1), p.247-252
Hauptverfasser:	Xiao, Guang-Hui, Jeffers, Michael, Bellacosa, Alfonso, Mitsuuchi, Yasuhiro, George F. Vande Woude, Testa, Joseph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Akt protein Animals Antibodies Apoptosis Apoptosis - drug effects Biological Sciences Biology Cancer Cell lines Cells Cellular immunity Chromones - pharmacology Cytoprotection Enzyme Activation - drug effects Flavonoids - pharmacology Genetics Hepatocyte Growth Factor - pharmacology Hepatocytes Humans Irradiation Ligands MAP Kinase Signaling System - drug effects Mice mitogen-activated protein kinase Morpholines - pharmacology NIH 3T3 cells Oncogene Proteins, Fusion - metabolism PC12 cells Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Protein Serine-Threonine Kinases - metabolism Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-met - metabolism Transfection Tumor Cells, Cultured
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