In vivo Testing of Subunit Vaccines against Malaria Sporozoites Using a Rodent System

To test the putative in vivo protective effects of antibodies to circumsporozoite (CS) protein repeats against malarial infection, different strains of mice were immunized against various repetitive regions of the Plasmodium yoelii CS protein in the form of synthetic peptides conjugated to keyhole l...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-12, Vol.84 (23), p.8647-8651
Hauptverfasser:	Lal, Altaf A., De La Cruz, Vidal F., Good, Michael F., Weiss, Walter R., Lunde, Milford, Maloy, W. Lee, Welsh, Judith A., McCutchan, Thomas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Protozoan - biosynthesis Antigens Antigens - immunology Antigens, Protozoan - genetics Antigens, Protozoan - immunology Biological and medical sciences DNA Epitopes Human protozoal diseases Immunoglobulin Isotypes - analysis Infections Infectious diseases Malaria Malaria - prevention & control Medical sciences Mice Nucleic Acid Hybridization Parasites Parasitic diseases Peptides - chemical synthesis Peptides - immunology Plasmodium - genetics Plasmodium - immunology Protozoal diseases Saponins Sporozoites Tropical medicine Vaccination Vaccines, Synthetic - immunology
Online-Zugang:	Volltext
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