Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury

Although phosphoinositide 3-kinases (PI3Ks) play beneficial pro-cell survival roles during tissue ischemia, some isoforms (γ and δ) paradoxically contribute to the inflammation that damages these same tissues upon reperfusion. We therefore considered the possibility that selectively inhibiting proin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-12, Vol.103 (52), p.19866-19871
Hauptverfasser:	Doukas, John, Wrasidlo, Wolfgang, Noronha, Glenn, Dneprovskaia, Elena, Fine, Richard, Weis, Sara, Hood, John, DeMaria, Anthony, Soll, Richard, Cheresh, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerial refueling Animals Biological Sciences Cell Proliferation Cells, Cultured Disease Models, Animal Edema Humans Inflammation Inflammation - drug therapy Inflammation - enzymology Inflammation - pathology Intercellular Signaling Peptides and Proteins - metabolism Models, Molecular Myocardial Ischemia - drug therapy Myocardial Ischemia - enzymology Myocardial Ischemia - genetics Myocardial Ischemia - pathology Myocardial reperfusion Myocardial reperfusion injury Myocardium Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - chemistry Phosphatidylinositol 3-Kinases - metabolism Physical trauma Protein isoforms Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - therapeutic use Protein Structure, Tertiary Protein Subunits - antagonists & inhibitors Protein Subunits - chemistry Protein Subunits - metabolism Rats Reperfusion Injury - drug therapy Reperfusion Injury - enzymology Reperfusion Injury - genetics Reperfusion Injury - pathology Rodents Signal Transduction Swine Vehicles
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