A Small-Molecule Inhibitor of Type III Secretion Inhibits Different Stages of the Infectious Cycle of Chlamydia trachomatis

The intracellular pathogen Chlamydia trachomatis possesses a type III secretion (TTS) system believed to deliver a series of effector proteins into the inclusion membrane (Inc-proteins) as well as into the host cytosol with perceived consequences for the pathogenicity of this common venereal pathoge...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-09, Vol.103 (39), p.14566-14571
Hauptverfasser:	Muschiol, Sandra, Bailey, Leslie, Gylfe, Åsa, Sundin, Charlotta, Hultenby, Kjell, Bergström, Sven, Elofsson, Mikael, Wolf-Watz, Hans, Normark, Staffan, Henriques-Normark, Birgitta
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 Proteins - metabolism Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents/chemistry/pharmacology Antibodies Bacteria Bacterial Proteins - antagonists & inhibitors Bacterial Proteins - metabolism Bacterial Proteins/antagonists & inhibitors/metabolism Biological Sciences Cell Differentiation Cell Membrane - metabolism Cells Cellular immunity Chlamydia Chlamydia Infections - drug therapy Chlamydia trachomatis Chlamydia trachomatis - cytology Chlamydia trachomatis - drug effects Chlamydia trachomatis - physiology Chlamydia trachomatis - ultrastructure Chlamydia trachomatis/cytology/drug effects/physiology/ultrastructure Dose-Response Relationship, Drug Incan culture Inclusion bodies Inclusion Bodies - ultrastructure Infections Infectious diseases Membrane Fusion Molecules Parasite hosts Pathogens Phosphoproteins - metabolism Protein Binding Protein Transport Proteins Secretion Yersinia pseudotuberculosis
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