Myogenic Factors That Regulate Expression of Muscle-Specific MicroRNAs

Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-06, Vol.103 (23), p.8721-8726
Hauptverfasser:	Rao, Prakash K., Kumar, Roshan M., Farkhondeh, Mina, Baskerville, Scott, Lodish, Harvey F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological Sciences Cells, Cultured Cellular differentiation Chromosomes, Mammalian - genetics Exons - genetics Gene expression Gene Expression Regulation Genes Genetic loci Genome - genetics Humans Mice MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Muscle development Muscle fibers Muscles - metabolism Myoblasts Myoblasts - metabolism MyoD Protein - metabolism Myogenin - metabolism Organ Specificity Polymerase chain reaction Protein Binding Ribonucleic acid RNA Stem cells Time Factors
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