An Essential Role for the Hematopoietic Transcription Factor Ikaros in Hypothalamic-Pituitary-Mediated Somatic Growth

Ikaros transcription factors play critical functions in the control of lymphohematopoiesis and immune regulation. Family members contain multiple zinc fingers that mediate DNA binding and homooligomerization or heterooligomerization. Ikaros is abundantly expressed in pituitary mammosomatotrophs, whe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-02, Vol.103 (7), p.2214-2219
Hauptverfasser:	Ezzat, Shereen, Mader, Rene, Fischer, Sandra, Yu, ShunJiang, Ackerley, Cameron, Asa, Sylvia L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arcuate Nucleus of Hypothalamus - cytology Arcuate Nucleus of Hypothalamus - metabolism Biological Sciences Deoxyribonucleic acid Developmental biology DNA Endocrine system Gene expression Gene expression regulation Gene Expression Regulation, Developmental Growth Hormone - deficiency Growth Hormone - pharmacology Growth Hormone-Releasing Hormone - genetics Growth Hormone-Releasing Hormone - metabolism Growth hormones Hematopoiesis Hormones Hypothalamo-Hypophyseal System - cytology Hypothalamo-Hypophyseal System - growth & development Hypothalamo-Hypophyseal System - metabolism Hypothalamus Hypothalamus - cytology Hypothalamus - metabolism Ikaros Transcription Factor - analysis Ikaros Transcription Factor - genetics Ikaros Transcription Factor - physiology Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor I - metabolism Lymphocytes Mice Mice, Mutant Strains Neurons Neurons - chemistry Neurons - metabolism Phenotypes Pituitary Gland - cytology Pituitary Gland - growth & development Pituitary Gland - metabolism Protein isoforms Rodents T lymphocytes
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