cDNA Cloning and Sequence of MAL, a Hydrophobic Protein Associated with Human T-Cell Differentiation

We have isolated a human cDNA that is expressed in the intermediate and late stages of T-cell differentiation. The cDNA encodes a highly hydrophobic protein, termed MAL, that lacks a hydrophobic leader peptide sequence and contains four potential transmembrane domains separated by short hydrophilic...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-04, Vol.84 (7), p.1997-2001
Hauptverfasser:	Alonso, Miguel A., Weissman, Sherman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 550301 - Cytology- Tracer Techniques AMINO ACID SEQUENCE Amino acids ANIMAL CELLS ANTIGENS Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Biological and medical sciences BIOLOGICAL MATERIALS Biotechnology BLOOD BLOOD CELLS BODY FLUIDS Carrier Proteins - genetics CELL CONSTITUENTS CELL DIFFERENTIATION Cell Line Cell lines CELL MEMBRANES Cells, Cultured CLONING Cloning, Molecular Complementary DNA CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES DISEASES DNA DNA - isolation & purification DNA - metabolism DNA SEQUENCING DNA-CLONING ELECTROPHORESIS Fundamental and applied biological sciences. Psychology Genetic engineering Genetic technics HeLa cells HEMIC DISEASES Humans ISOTOPES LEUKEMIA LEUKOCYTES LIGHT NUCLEI LYMPHOCYTES MATERIALS MEMBRANE PROTEINS Membrane Proteins - genetics Membrane Transport Proteins MEMBRANES MESSENGER-RNA Methods. Procedures. Technologies Molecular cloning MOLECULAR STRUCTURE Molecules Myelin and Lymphocyte-Associated Proteolipid Proteins Myelin Proteins NEOPLASMS NUCLEI NUCLEIC ACIDS ODD-ODD NUCLEI ORGANIC COMPOUNDS PHOSPHORUS 32 PHOSPHORUS ISOTOPES Protein Biosynthesis PROTEINS Proteins - genetics Proteolipids RADIOISOTOPES RECEPTORS RECOMBINANT DNA RNA RNA, Messenger - genetics SOMATIC CELLS STRUCTURAL CHEMICAL ANALYSIS T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - immunology TUMOR CELLS
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