$Structures of Active Conformations of G$_{i\alpha1}$ and the Mechanism of GTP Hydrolysis$

Structures of Active Conformations of G$_{i\alpha1}$ and the Mechanism of GTP Hydrolysis

Mechanisms of guanosine triphosphate (GTP) hydrolysis by members of the G protein α subunit-p21$^{ras}$ superfamily of guanosine triphosphatases have been studied extensively but have not been well understood. High-resolution x-ray structures of the GTPγS and GDP·AIF$_4^-$ complexes formed by the G...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-09, Vol.265 (5177), p.1405-1412
Hauptverfasser:	Coleman, David E., Berghuis, Albert M., Lee, Ethan, Linder, Maurine E., Gilman, Alfred G., Sprang, Stephen R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Atoms Crystals Datasets Electron density Hydrogen bonds Hydrolysis Molecules Nucleotides Oxygen Phosphates Research Article
Online-Zugang:	Volltext
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