A Recognition Site on Synthetic Helical Oligonucleotides for Monoclonal Anti-Native DNA Autoantibody

The binding site in native DNA for a murine monoclonal anti-DNA autoantibody was investigated by measurements of competitive binding of a series of synthetic helical oligonucleotides. The antibody bound to a (dG-dC)3 or (dG-dC)4 core in the center of a base-paired octadecanucleotide. Reactions of an...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-06, Vol.83 (12), p.4469-4473
Hauptverfasser:	Stollar, B. David, Zon, Gerald, Pastor, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, immunoglobulins Antibodies, Monoclonal - immunology Antibody Specificity Atoms Autoantibodies Autoantibodies - immunology Base Sequence Binding sites Biological and medical sciences Chemical bases DNA DNA - immunology Epitopes Fundamental and applied biological sciences. Psychology Fundamental immunology Hypoxia Lupus Erythematosus, Systemic - immunology Mice Models, Molecular Molecular immunology Monoclonal antibodies Nucleic Acid Conformation Nucleic acids Oligonucleotides Polymers
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