Activation function 2 (AF2) of estrogen receptor-α is required for the atheroprotective action of estradiol but not to accelerate endothelial healing

17β-Estradiol (E2) regulates estrogen receptor-α (ERα) target gene transcription through the two independent activation functions (AFs), AF1 and AF2, located in the N-terminal and ligand binding domain of ERα, respectively. We previously reported that ERα is required for the E2 atheroprotective acti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (32), p.13311-13316
Hauptverfasser:	Billon-Galés, Audrey, Krust, Andrée, Fontaine, Coralie, Abot, Anne, Flouriot, Gilles, Toutain, Céline, Berges, Hortense, Gadeau, Alain-Pierre, Lenfant, Françoise, Gourdy, Pierre, Chambon, Pierre, Arnal, Jean-François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - metabolism Aorta - pathology Atherosclerosis - pathology Atherosclerosis - prevention & control Atherosclerotic plaque Biological Sciences Body Weight - drug effects Cholesterols Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene Expression Regulation - drug effects Genotypes Healing HeLa Cells Hep G2 Cells Humans Lesions Mice Mice, Knockout Organ Size - drug effects Protective Agents - pharmacology Proteins Reproducibility of Results Transcriptional Activation - drug effects Uterus Uterus - drug effects Uterus - metabolism Uterus - pathology Wound Healing - drug effects
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