Glycosylation of the T-Cell Antigen-Specific Receptor and its Potential Role in Lectin-Mediated Cytotoxicity

Cytotoxic T lymphocytes (CTLs) normally destroy only those cells (``target cells'') whose surface antigens they recognize. However, in the presence of lectins such as Con A, CTLs destroy virtually any cell, regardless of its antigens. The oligosaccharides of the T-cell antigen-specific rec...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1986-03, Vol.83 (6), p.1852-1856
Hauptverfasser:	Hubbard, S. Catherine, Kranz, David M., Longmore, Gregory D., Sitkovsky, Michail V., Eisen, Herman N.
Format:	Artikel
Sprache:	eng
Schlagworte:	550601 - Medicine- Unsealed Radionuclides in Diagnostics ALKALI METAL COMPOUNDS Analysis of the immune response. Humoral and cellular immunity ANIMAL CELLS ANIMALS Antibodies Antibodies, Monoclonal - immunology ANTIGENS BETA DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS CARBOHYDRATES Cell Line CHEMISTRY Concanavalin A - pharmacology CONNECTIVE TISSUE CELLS Cytotoxicity Cytotoxicity, Immunologic - drug effects DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Fundamental and applied biological sciences. Psychology Fundamental immunology Gels Glycoside Hydrolases HALIDES HALOGEN COMPOUNDS Immunobiology INORGANIC PHOSPHORS INTERMEDIATE MASS NUCLEI IODIDES IODINE 125 IODINE COMPOUNDS IODINE ISOTOPES ISOTOPE APPLICATIONS ISOTOPES LECTINS Leukemia, Experimental LEUKOCYTES LYMPHOCYTES MAMMALS Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase MATERIALS MEMBRANE PROTEINS MICE Mice, Inbred BALB C Mice, Inbred C57BL NUCLEI ODD-EVEN NUCLEI OLIGOSACCHARIDES Oligosaccharides - analysis ORGANIC COMPOUNDS Organs and cells involved in the immune response PHOSPHORS Polysaccharides PROTEINS RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RADIORECEPTOR ASSAY RECEPTORS Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism RODENTS SACCHARIDES SODIUM COMPOUNDS SODIUM IODIDES SOMATIC CELLS T cell antigen receptors T lymphocytes T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Cytotoxic - metabolism TOXICITY TRACER TECHNIQUES VERTEBRATES
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