Control of Oxidative Metabolism and Oxygen Delivery in Human Skeletal Muscle: A Steady-State Analysis of the Work/Energy Cost Transfer Function

The concept of transfer function for organ performance (work output vs. biochemical input) is developed for skeletal and cardiac muscle under steady-state exercise conditions. For metabolic control by the ADP concentration, the transfer function approximates a Michaelis-Menten hyperbola. Variation o...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1985-12, Vol.82 (24), p.8384-8388
Hauptverfasser:	Chance, B., Leigh, J. S., Clark, B. J., Maris, J., Kent, J., Nioka, S., Smith, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine triphosphatases Adenosine Triphosphate - metabolism Biochemistry Biological and medical sciences Biomechanics. Biorheology Cellular metabolism Creatine Cytosol - metabolism Energy Metabolism Fundamental and applied biological sciences. Psychology Humans Hydrogen-Ion Concentration Hyperbolas Hypoxia - metabolism Kinetics Magnetic Resonance Spectroscopy Metabolism Mitochondria, Muscle - metabolism Muscles - metabolism Oxygen Oxygen - metabolism Phosphates Phosphates - metabolism Phosphocreatine - metabolism Physical Exertion Space life sciences Tissues, organs and organisms biophysics Transfer functions
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