Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial ro...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-04, Vol.113 (17), p.4830-4835
Hauptverfasser:	Saunderson, Emily A., Spiers, Helen, Mifsud, Karen R., Gutierrez-Mecinas, Maria, Trollope, Alexandra F., Shaikh, Abeera, Mill, Jonathan, Reul, Johannes M. H. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain CpG Islands Dentate Gyrus - drug effects Dentate Gyrus - metabolism DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - drug effects DNA Methyltransferase 3A Early Growth Response Protein 1 - genetics Freezing Reaction, Cataleptic - drug effects Gene expression Gene Expression Regulation - drug effects Genes, fos Genes, Immediate-Early - drug effects Histone Code - drug effects Male Neurons Phosphorylation Promoter Regions, Genetic - genetics Rats Rats, Wistar S-Adenosylmethionine - pharmacology Stress, Physiological - genetics Stress, Psychological - genetics Swimming
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