A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait

In humans, the connection between sleep and mood has long been recognized, although direct molecular evidence is lacking. We identified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with familial advanced sleep phase accompanied by higher Beck Depression Inventor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-03, Vol.113 (11), p.E1536-E1544
Hauptverfasser:	Zhang, Luoying, Hirano, Arisa, Hsu, Pei-Ken, Jones, Christopher R., Sakai, Noriaki, Okuro, Masashi, McMahon, Thomas, Yamazaki, Maya, Xu, Ying, Saigoh, Noriko, Saigoh, Kazumasa, Lin, Shu-Ting, Kaasik, Krista, Nishino, Seiji, Ptáček, Louis J., Fu, Ying-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Affect - physiology Aged Amino Acid Sequence Animals Biological Sciences Circadian Clocks - genetics Circadian rhythm Circadian rhythms Emotions Female Genotype & phenotype Humans Male Mental depression Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Middle Aged Molecular Sequence Data Period Circadian Proteins - genetics Period Circadian Proteins - metabolism Photoperiod PNAS Plus Protein Stability Proteins Rodents Seasonal Affective Disorder - genetics Seasonal variations Seasons Sleep Sleep Disorders, Circadian Rhythm - genetics Transgenic animals
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