Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways

Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that include...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-01, Vol.113 (2), p.434-439
Hauptverfasser:	Kirkby, Nicholas S., Chan, Melissa V., Zaiss, Anne K., Garcia-Vaz, Eliana, Jiao, Jing, Berglund, Lisa M., Verdu, Elena F., Ahmetaj-Shala, Blerina, Wallace, John L., Herschman, Harvey R., Gomez, Maria F., Mitchell, Jane A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Cardiac and Cardiovascular Systems Clinical Medicine Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclosporine - pharmacology Cytokines - metabolism Female Gene Expression Regulation, Enzymologic - drug effects Germ-Free Life Kardiologi Kidney - drug effects Kidney - metabolism Klinisk medicin Lipopolysaccharides - pharmacology Luciferases - metabolism Male Medical and Health Sciences Medicin och hälsovetenskap Mice, Inbred C57BL NF-kappa B - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction - drug effects Tissue Distribution - drug effects Transcription, Genetic - drug effects
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