Immunomodulatory spherical nucleic acids

Immunomodulatory nucleic acids have extraordinary promise for treating disease, yet clinical progress has been limited by a lack of tools to safely increase activity in patients. Immunomodulatory nucleic acids act by agonizing or antagonizing endosomal toll-like receptors (TLR3, TLR7/8, and TLR9), p...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-03, Vol.112 (13), p.3892-3897
Hauptverfasser:	Radovic-Moreno, Aleksandar F., Chernyak, Natalia, Mader, Christopher C., Nallagatla, Subbarao, Kang, Richard S., Hao, Liangliang, Walker, David A., Halo, Tiffany L., Merkel, Timothy J., Rische, Clayton H., Anantatmula, Sagar, Burkhart, Merideth, Mirkin, Chad A., Gryaznov, Sergei M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antigens Antigens - chemistry Biological Sciences Cell Line Comparative analysis fatty liver Female Humans Immunity, Innate Immunohistochemistry immunomodulators Immunotherapy Liver Cirrhosis - pathology Lymphoma Lymphoma - therapy Medical treatment Mice Mice, Inbred C57BL Nanomedicine - methods Nanoparticles - chemistry neoplasms Neoplasms, Experimental - therapy Non-alcoholic Fatty Liver Disease - therapy Nucleic Acid Conformation nucleic acids Nucleic Acids - chemistry Nucleic Acids - therapeutic use oligonucleotides Oligonucleotides - therapeutic use Physical Sciences Proteins Rodents Toll-Like Receptors - agonists
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