Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

Significance Fc gamma receptor I (FcγRI) contributes to protective immunity against bacterial infections, but exacerbates certain autoimmune diseases. It is the sole high-affinity receptor for IgG and plays a significant role in immunotherapy. To date, there is no structural information available on...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-01, Vol.112 (3), p.833-838
Hauptverfasser:	Lu, Jinghua, Chu, Jonathan, Zou, Zhongcheng, Hamacher, Nels B., Rixon, Mark W., Sun, Peter D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence antibodies autoimmune diseases bacterial infections BASIC BIOLOGICAL SCIENCES Binding Sites Biological Sciences CD64 crystal structure engineering FcgRI glycan recognition Humans IgG recognition immunity immunoglobulin G Immunoglobulin G - chemistry immunotherapy ligands Molecular Sequence Data Polysaccharides - chemistry Protein Conformation Receptors, IgG - chemistry Sequence Homology, Amino Acid
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