Pathway-specific engagement of ephrinA5-EphA4/EphA5 system of the substantia nigra pars reticulata in cocaine-induced responses

The nucleus accumbens (NAc) serves as a key neural substrate that controls acute and adaptive behavioral responses to cocaine administration. In this circuit, inputs from the NAc are transmitted through two parallel pathways, named the direct and indirect pathways, and converge at the substantia nig...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-06, Vol.108 (24), p.9981-9986
Hauptverfasser:	Kimura, Kensuke, Hikida, Takatoshi, Yawata, Satoshi, Yamaguchi, Takashi, Nakanishi, Shigetada
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Local - administration & dosage Anesthetics, Local - pharmacology Animals Antibodies Basal ganglia Biological Sciences Cocaine Cocaine - administration & dosage Cocaine - pharmacology Ephrin-A5 - genetics Ephrin-A5 - metabolism Gene expression Gene Expression Profiling Genomes Immunohistochemistry Locomotion Messenger RNA Mice Mice, Transgenic Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Motor Activity - drug effects Neural Pathways - drug effects Neurochemistry Neurons Neurons - drug effects Neurons - metabolism Neurotransmitters Oligonucleotide Array Sequence Analysis Phosphorylation Phosphorylation - drug effects Receptor, EphA4 - genetics Receptor, EphA4 - metabolism Receptor, EphA5 - genetics Receptor, EphA5 - metabolism Receptors Reverse Transcriptase Polymerase Chain Reaction Rodents Studies Substantia nigra Substantia Nigra - drug effects Substantia Nigra - metabolism Supernova remnants Tetanus Toxin - genetics Tetanus Toxin - metabolism Up-Regulation - drug effects
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