Chimpanzees as an animal model for human norovirus infection and vaccine development

Noroviruses are global agents of acute gastroenteritis, but the development of control strategies has been hampered by the absence of a robust animal model. Studies in chimpanzees have played a key role in the characterization of several fastidious hepatitis viruses, and we investigated the feasibil...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-01, Vol.108 (1), p.325-330
Hauptverfasser:	Bok, Karin, Parra, Gabriel I., Mitra, Tanaji, Abente, Eugenio, Shaver, Charlene K., Boon, Denali, Engle, Ronald, Yu, Claro, Kapikian, Albert Z., Sosnovtsev, Stanislav V., Purcell, Robert H., Green, Kim Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibodies Antibodies, Viral - blood Antigens B lymphocytes Base Sequence Biological Sciences Biopsies Biopsy Disease Models, Animal Feces Fluorescent Antibody Technique Gastroenteritis Gastroenteritis - immunology Gastroenteritis - prevention & control Gastroenteritis - virology Gastroenterology Gastrointestinal diseases Genomes Hepatitis Humans Immunity Immunization Immunogenicity Immunohistochemistry Infection Infections Injections, Intramuscular Intestine Intestine, Small - virology lamina propria Liver Molecular Sequence Data Monkeys & apes Mucous Membrane - virology Norovirus Norwalk virus Norwalk virus - genetics Pan troglodytes Replication RNA Sequence Analysis, DNA Time Factors Vaccination Vaccines Vaccines, Virus-Like Particle - administration & dosage Vaccines, Virus-Like Particle - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus-like particles Viruses
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