VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity

Dorsal root ganglia (DRG) neurons, including the nociceptors that detect painful thermal, mechanical, and chemical stimuli, transmit information to spinal cord neurons via glutamatergic and peptidergic neurotransmitters. However, the specific contribution of glutamate to pain generated by distinct s...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (51), p.22296-22301
Hauptverfasser:	Scherrer, Grégory, Low, Sarah A., Wang, Xidao, Zhang, Jie, Yamanaka, Hiroki, Urban, Rochelle, Solorzano, Carlos, Harper, Blaine, Hnasko, Thomas S., Edwards, Robert H., Basbaum, Allan I., Jan, Lily Yeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid transport system XAG Animals Behavior, Animal - drug effects Biological Sciences Capsaicin Capsaicin - pharmacology Chemical stimuli Cold Temperature Dorsal root ganglia Fixatives - pharmacology Formaldehyde - pharmacology Ganglia, Spinal - metabolism Gene Expression Regulation Genes Glutamic acid transporter Heat Hot Temperature Hyperalgesia Hyperalgesia - genetics Hyperalgesia - metabolism Hypersensitivity Mechanical stimuli Mice Mice, Knockout mRNA Nerves Nervous system trauma Neurons Neuropathy Neurotransmitters Nociceptors Nociceptors - metabolism Pain Pain - genetics Pain - metabolism Pain perception Physical trauma Proteins Rodents Sensory neurons Sensory System Agents - pharmacology Spinal cord Tissues Vesicular Glutamate Transport Protein 2 - biosynthesis Vesicular Glutamate Transport Protein 2 - genetics
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