Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

EZH2, the catalytic subunit of the PRC2 complex, catalyzes the mono- through trimethylation of lysine 27 on histone H3 (H3K27). Histone H3K27 trimethylation is a mechanism for suppressing transcription of specific genes that are proximal to the site of histone modification. Point mutations of the EZ...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-12, Vol.107 (49), p.20980-20985
Hauptverfasser:	Sneeringer, Christopher J., Scott, Margaret Porter, Kuntz, Kevin W., Knutson, Sarah K., Pollock, Roy M., Richon, Victoria M., Copeland, Robert A., Wells, James A.
Format:	Artikel
Sprache:	eng
Schlagworte:	B cell lymphoma Biological Sciences Catalysis Cell lines DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer of Zeste Homolog 2 Protein Enzyme substrates Enzymes Genes Genetic mutation Histones Histones - metabolism Humans Kinetics Lymphoma, B-Cell - enzymology Lymphoma, B-Cell - etiology Lymphoma, B-Cell - genetics Lysine - metabolism Methylation Nucleosomes Point Mutation Polycomb Repressive Complex 2 Stem cells Transcription Factors - genetics Transcription Factors - metabolism
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